Microchips for identification of SNPs in CYP2C9 and VKORC1 genes

Therapeutic importance and risk associated with the anticoagulant warfarin prescribed for blood clot treatment has necessitated the need for testing and screening of patients for single-nucleotide polymorphisms (SNPs) in two genes: CYP2C9 (encodes the main enzyme involved in warfarin metabolism) and VKORC1 (encodes the vitamin K-epoxide reductase protein, the target enzyme of warfarin). Diagnostic tests for these SNPs identification are recommended to improve safety of warfarin treatment in patients to addressnarrow therapeutic index of warfarin.

LUMEX INSTRUMENTS presents AiraDNA-Warfarin microchip PCR kit for simultaneous identification of CYP2C9 (*2 and *3) and VKORC1 (-1639G/A) polymorphisms that can help clinicians to determine the warfarin dosage. The microchips with lyophilized PCR reagents mixes just need an addition of the test sample with a buffer into the individual reactors of the microchip.